Cuban state security agents have blocked the organiser of pro-democracy rallies planned for later on Monday from leaving his home.
Security forces surrounded the home of Yunior García and those of other leading activists on Sunday.
The ruling Communist party has banned the protests, which it says are a US-backed attempt at overthrowing the government.
The authorities arrested scores of people following protests in July.
Unauthorised public gatherings are illegal in Cuba and those who turn out to march risk being jailed.
The fact that thousands of people joined July’s protests chanting “freedom” and “down with dictatorship” showed the level of discontent many in Cuba feel after more than six decades of communist rule.
In the wake of the July protests and the arrests which followed, Mr García set up a group on Facebook called Archipiélago, which sought official permission to organise peaceful demonstrations in the Cuban capital, Havana, and other cities to demand “rights for all Cubans” and the release of political prisoners.
Permission was denied but dissidents have insisted that their protest will go ahead as planned.
The BBC’s Cuba correspondent, Will Grant, says that they insist people will show their exhaustion with communist rule.
Our correspondent says that there is also defiance on the part of the government and its supporters that what they consider a US-backed attempt at an overthrow will not be permitted to gather momentum.
Mr García had planned to walk to Havana’s waterfront promenade, the Malecón, carrying a white rose a day ahead of the main protests.
But early on Sunday, state security agents and government supporters blocked the playwright from leaving his home.
As he attempted to communicate from a window of his apartment, pro-revolutionary neighbours living above him lowered a large Cuban flag to block him from view.
In a telephone interview with BBC News Mundo, Mr García said that his internet connection had been disrupted.
“I think they’re trying to keep me incommunicado,” he told BBC Mundo’s Lioman Lima.
Mr García also said that “the changes in this country are unstoppable”.
Other dissidents have also reported seeing state security agents patrolling the streets in front of their homes.
A number of Cuban journalists reported having been told not to leave their homes on Monday.
The Spanish news agency Efe said that the Cuban government withdrew press credentials from five of its journalists. were later reinstated and the Spanish government is demanding that the remaining three also be returned.
